Why it matters: Japanese researchers have launched clinical trials for a groundbreaking drug that could enable humans to regrow natural teeth, potentially revolutionizing dental care and eliminating the need for dentures and implants. As reported by MedicalXpress, the treatment targets dormant tooth buds hidden beneath our gums, challenging the long-held belief that humans can only grow two sets of teeth.
The Big Picture: Led by Dr. Katsu Takahashi at Kyoto University Hospital, the trials began in October with ambitious goals:
- Initial testing on 30 healthy males aged 30-64
- Focus on safety and feasibility
- Targeting 2030 for public availability
- Estimated cost of 1.5 million yen per treatment
Scientific Breakthrough: The drug works by blocking a protein called USAG-1 that inhibits tooth growth:
- Activates dormant tooth buds
- Successfully tested on mice and ferrets (WorldofBuzz)
- No major side effects reported in animal studies
- Could benefit 0.1% of population with congenital tooth deficiency (CNA)
Expert Perspective: While the research shows promise, some scientists urge caution. “The assertion that humans possess latent tooth buds capable of producing a third set of teeth is both revolutionary and controversial,” says Chengfei Zhang, clinical professor at the University of Hong Kong.
Looking Forward: If successful, the treatment could particularly benefit Japan’s aging population, where over 90% of those 75 and older have at least one missing tooth.
